Drosophila oogenesis: Coordinating germ line and soma
نویسنده
چکیده
A new function for Delta-Notch signaling has been discovered in Drosophila oogenesis: Delta expressed in the germ cells activates Notch in the surrounding somatic follicle cells to control their differentiation, proliferation and morphogenesis.
منابع مشابه
Sex determination in Drosophila: sis-b, a major numerator element of the X:A ratio in the soma, does not contribute to the X:A ratio in the germ line.
In soma and germ cells of Drosophila, the X:A ratio builds a primary signal for sex determination, and in both tissues Sex-lethal (Sxl) function is required for cells to enter the female pathway. In somatic cells of XX animals, the products of X-chromosomal elements of the X:A ratio activate Sxl. Here I show that sisterless-b (sis-b), which is the X-chromosomal element of the somatic X:A ratio ...
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To investigate the mechanism of sex determination in the germ line, we analyzed the fate of XY germ cells in ovaries, and the fate of XX germ cells in testes. In ovaries, germ cells developed according to their X:A ratio, i.e., XX cells underwent oogenesis, XY cells formed spermatocytes. In testes, however, XY and XX germ cells entered the spermatogenic pathway. Thus, to determine their sex, th...
متن کاملSex determination in the germ line of Drosophila depends on genetic signals and inductive somatic factors.
We have analyzed the mechanism of sex determination in the germ line of Drosophila by manipulating three parameters: (1) the ratio of X-chromosomes to sets of autosomes (X:A); (2) the state of activity of the gene Sex-lethal (Sxl), and (3) the sex of the gonadal soma. To this end, animals with a ratio of 2X:2A and 2X:3A were sexually transformed into pseudomales by mutations at the sex-determin...
متن کاملRegulatory and functional interactions between the somatic sex regulatory gene transformer and the germline genes ovo and ovarian tumor.
In Drosophila, compatibility between the sexually differentiated state of the soma and the sex chromosome constitution of the germline is required for normal gametogenesis. In this study, we defined important aspects of the soma-germline interactions controlling early oogenesis. In particular, the sex-specific germline activity of the ovarian tumor promoter was found to be dependent upon somati...
متن کاملmago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in Drosophila.
Establishment of the anteroposterior and dorsoventral axes in the Drosophila egg chamber requires reciprocal signaling between the germ line and soma. Upon activation of the Drosophila EGF receptor in the posterior follicle cells, these cells signal back to the oocyte, resulting in a reorganization of the oocyte cytoplasm and anterodorsal migration of the oocyte nucleus. We demonstrate that the...
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عنوان ژورنال:
- Current Biology
دوره 11 شماره
صفحات -
تاریخ انتشار 2001